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Psychiatry General 21f37460

Blood of 45 yrs old male shows -HVA. This patient is most likely to show -

A
PCC
B
Schizophrenia
C
Depression
D
Parkinson's ds
High-Yield Explanation
Some guides have given Schizophrenia as the answers. But they are wrong. Read below : - Homovanillic acid (HVA) is the major metabolite of dopamine. Schizophrenia is characterized by hyperactivity of dopaminergic system. However, HVA is not raised in Schizophrenia → Which questioned the dopamine hypothesis of schizophrenia. Dopamine is decreased in parkinsonism →HVA level is decreased. Though dopamine is decreased in depression, dopamine and HVA are raised in psychotic depression: -"Elevated levels of HVA have been reported in psychotic depression, suggesting increased dopamine activity in this subtype of depression" Imidazole acetic acid

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