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Surgery General 21df570b

All are true about succinate dehydrogenase deficient gastrointestinal stromal tumor (SDH-deficient GIST) except

A
More common in children and young adult
B
Negative for DOG-1
C
Most common location is stomach
D
Associated with Carney-Stratakis syndrome
High-Yield Explanation
Answer- B. Negative for DOG-1Succinate dehydrogenase (SDH) deficient - Gastrointestinal Stromal Tumors (GIST)-Pathological features-SDH deficient - GISTs do not have c-KIT mutation --> absence of c-KIT mutation.They strongly express KIT and DOG1/Ano-1, but do not have KIT mutation.Clinical features-They maY be associated with :-Carney stratakis syndrome - Paraganglioma with familial GISTCarney triadThese tumors have tendency to appear in children and young adultsThey occur exclusively in stomach.

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