Increased IgA deposits are seen in -
High-Yield Explanation
Henoch schonlein purpura
This syndrome consists of
Pruritic skin lesions characteristically involving the extensor surfaces of arms and legs as well as buttocks.
Abdominal manifestations → Pain, vomiting, bleeding
Nonnzigratory arthralgia
Renal abnormalities
The disease most commonly affects children between 3 to 8 years.
Renal manifestations
Gross or microscopic hematuria
Proteinuria
Nephrotic syndrome
There is deposition of IgA, sometimes with IgG and C3, in the mesangial region.
IgA is deposited in the glomerular mesangium in a distribution similar to that of IgA nephropathy. This has led to the concept that IgA nephropathy and Henoch-Schonlein purpura are spectra of the same disease.