Pathology General 21aa09e9

Xeroderma pigmentosum is characterized by

AutosomaL dominant inheritance

Inability to repair sunlight induced damage to DNA

Irregular accumulation of melanin in the basal cell layer

Acanthosis of epithelium with elongation of rete ridges

High-Yield Explanation

Xeroderma pigmentosum is a genetically determined disorder, in which defective DNA repair mechanisms lead to chronic UV damage and subsequent development of different sun related skin tumors, including melanoma, in sun exposed areas.

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Xeroderma pigmentosum is characterized by

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