Proteasome inhibition is seen with

It is a proteasome inhibitor - an anticancer drugBoezomib was first approved for use in relapsing or refractory multiple myeloma and is now widely used in the first-line treatment of multiple myeloma. This agent is thought to exe its main cytotoxic effects through inhibition of the 26 S proteasome, which results in down-regulation of the nuclear factor kappa B (NF-kB) signaling pathway. Of note,inhibition of NF-kB has been shown to restore chemosensitivity.Ref: Sharma and Sharma 3rd ed/pg 871; Katzung; 13th edition; Page no: 971