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Pharmacology General 20c048fc

Neuropathy caused by INH increases in all except?

A
Uremia
B
Hypehyroidism
C
Diabetes mellitus
D
Poor nutrition
High-Yield Explanation
Ans. is'b'i.e., Hypehyroidismisoniazid induced peripheral neuropathy:Peripheral neuropathy is observed in 10 to 20% of patients given doses greater than 5 mg/kg/d, but it is infrequently seen with the standard 300-mg adult dose.Peripheral neuropathy is more likely to occur in slow acetylators and patients with predisposing conditions such as malnutrition, alcoholism, iliabetes, AIDS, and uremia.

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