A 56-year-old man presented with bony pain. X-ray of skull showing which lesions in brain:

Ans. a. Paget's diseasePAGET DISEASE OF BONE (OSTEITIS DEFORMANS)Common, localized disorder of bone remodeling caused by increases osteoclastic activity followed by increasing osteoblastic activity that forms poor-quality bone.In Paget disease; Serum Ca2+, phosphorus, and PTH levels are normal.ALP value elevated in Paget disease.Mosaic pattern of woven and lamellar bone (osteocytes within lacunae in chaotic juxtapositions); chalk-stick fractures seen in long bone.Increases blood flow from increases arteriovenous shunts may cause high-output heart failure.It Increases risk of osteogenic sarcoma.Due to skull thickening; Hat size increaseHearing loss is more commonly seen due to auditory foramen narrowing.STAGES OF PAGET DISEASELytic--osteoclastsMixed--osteoclasts +osteoblastsSclerotic--osteoblastsQuiescent--minimal osteoclast/osteoblast activity Treatment: Bisphosphonates