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Psychiatry Schizophrenia 1ff8ffa6

Most important receptors involved with schizophrenia are?

A
GABAA
B
GABAB
C
D2
D
5-HT1
High-Yield Explanation
Ans. is 'c' i.e., D2 * Dopamine hypothesis is the most accepted hypothesis for schizophrenia. There is hyperactivity of dopaminergic system. This hypothesis is supported by:i) Amphetamine and cocaine which release dopamine in central synapses induce schizophrenia like symptoms; andii) Antipsychotic drugs control the schizophrenic symptoms by blocking dopamine (D2) receptors.* Other neurotransmitters involved are: - Increased serotonin, Decreased GABA, variable change (Increased or decreased) glutamate, and increased norepinephrine.

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