The following antiarrhythmic drug has the most prominent anticholinergic action

Disopyramide It is a quinidine like Class IA drug that has prominent cardiac depressant and anticholinergic actions, but no a adrenergic blocking propey. Disopyramide usually has no effect on sinus rate because of opposing direct depressant and antivagal actions. Ref:- kd tripathi; pg num:-530