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Pathology All India exam 1ef2093b

Following injection of lymphokines, the same class of immunoglobulin are produced. This is to be referred as -

A
Clonal selection
B
Hybridisation
C
Class switching
D
noe of the above
High-Yield Explanation
B-cells are able to make a specific antibody against a specific antigen. * It is due to present of specific receptor on B-cells - B-cell receptor (BCR), that is usually an immunoglobulin Ig M or Ig D. * An antigen interacts with B-cell that shows best fit by viue of its BCR. * The antigen binds to this receptor, and the B-cell is stimulated to divide and form a clone (clonal selection). * This clone of cells will become plasma cells that will secretes antibody of a paicular specificity and same class. * Although, B-cells are the major source of antibodies (after their conversion into plasma cells), Helper - T cells are alsoimpoant. * Helper T-cells activate B-cells by secreting cytokines (lymphokines). o In antibo* B-cells are able to make a specific antibody against a specific antigen. * It is due to present of specific receptor on B-cells - B-cell receptor (BCR), that is usually an immunoglobulin Ig M or Ig D. * An antigen interacts with B-cell that shows best fit by viue of its BCR. * The antigen binds to this receptor, and the B-cell is stimulated to divide and form a clone (clonal selection). dy formation T-cells are involved earlier than B-cells. REF: ROBBINS pathology 10th edition

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