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Pharmacology General 1ee2c496

Mechanism of action of epinephrine in cardiopulmonary resuscitation is -

A
Increase myocardical demand
B
Increase SA node activity
C
Peripheral vasoconstriction and directing blood flow to hea
D
Ratio of blood flow to epicardium and endocardium decreases
High-Yield Explanation
Ans. is 'b i.e., Increase S.A. node activity "Epinephrine speeds the hea by accelerating the slow depolarization of SA nodal cells that takes place during diastole, i.e., during phase 4 of the action potential. Consequently, the transmembrane potential of the pacemaker cells rises more rapidly to the threshold level of action potential initiation. The amplitude the action potential and the maximal rate of depolarization (phase 0) also are increased."

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