Cold haemagglutinin is associated with-

The cold hemagglutinin antibody titre is very high at 4 degree centigrade and very low at 37 degree centigrade which is confirmed by donath landsteiner test The Donath-Landsteiner test is a blood test to detect harmful antibodies related to a rare disorder called paroxysmal cold hemoglobinuria. These antibodies form and destroy red blood cells when the body is exposed to cold temperatures reference: textbook of Pathology, 7th edition ,author Harsha Mohan ,page number 289.