A vasopressin analogue does not produce therapeutic effect through vasopressin V-2 receptor in which of the following -

Ans is option 2 bleeding esophageal varices Vasopressin stops bleeding of esophageal varices by constricting the vessels through V1 receptors. All other act through V2 receptors on kidney liver and vascular endothelium V 1 receptors are present on blood vessels smooth muscles CNS platelet etc.. Ref.. KDT 4/e p 539-541