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Pharmacology General 1e25d867

All of the following statements regarding bioavailability of a drug are true except:

A
It is a fraction of administered drug that reaches the systemic circulation in unchanged form
B
Bioavailability of an orally administered drug can be calculated by comparing the Area Under Curve after oral and intravenous administration
C
Low oral availability always and necessarily means poor absorption
D
Bioavailability can be determined from plasma concentration or urinary excretion data.
High-Yield Explanation
- Bioavailability is the fraction of administered drug that reaches systemic circulation in unchanged form. So it depends on Absorption and first pass metabolism. - In case of oral bioavailability, it may be low due to decreased absorption or high first pass metabolism.
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