Treatment of choice in 11 years old children with hepatitis C infections ?
High-Yield Explanation
Treatment of Hepatitis C : Sustained virologic response are achieved in only 8-35%of patients given recombinant interferon monotherapy. However significantly higher sustained virologic responses are attained(30-40%)by combining interferon with Ribavarin at 15mg/kg/day Long acting pegylated interferons have been subsequently developed based on the premise that more sustained drug levels would result in greater antiviral activity Interferons have been well tolerated in children Ref : ESSENTIAL PEDIATRICS,O.P.GHAI, PG NO:195,7th edition