Biochemistry Nutrition & Digestion 1db3323e Toxicity of ethanol is due to: A Increased NADH/NAD+ ratio B Decreased lactate/pyruvate ratio C Inhibition of gluconeogenesis D Stimulation of fatty acid oxidation High-Yield Explanation Ans. A. Increased NADH/NAD+ ratioHigh concentration of NADH leads to high NADH/NAD+ ratio. This is the basic cause of all metabolic alteration in alcoholism.