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Biochemistry Molecular Genetics 1da96323

Sickle cell anemia is the clinical manifestation of homozygous genes for an abnormal hemoglobin molecule. The event responsible for the mutation in the B chain is:

A
Insertion
B
Deletion
C
Nondisjunction
D
Point mutation
High-Yield Explanation
Ans. D. Point mutationThe mutation in HbS is an example ofPoint mutationPartially acceptable mis-sense mutationTransversionBase substitution.Nonconservative mutation

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