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Medicine General 1d58c554

The differentiating feature b/w Ectopic ACTH secretion and Cushing syndrome is:

A
Hypokalemic alkalosis
B
Clinical features of cushing syndrome
C
Hyperpigmentation
D
Hypeension
High-Yield Explanation
Answer is A (Hypokalemic alkalosis); Wypokalemia, hypochloremia and metabolic alkalosis are present paicularly with ectopic production of ACTH' --Harrison 16th/2135 "The ectopic production of CRH results in clinical, biochemical and radiologic feature indistinguishable from those caused by hypersecretion of pituitary ACTH. The Typical signs and symptoms of Cushing's syndrome may be absent or minimal with ectopic ACTH production and hypokalemic alkalosis is a prominent manifestation." -- Harrison

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