Pyruvate can be a substrate of all except

BIOSYNTHESIS OF HEME - Heme can be synthesized by almost all the tissues in the body. Heme is synthesized in the normoblasts, but not in the matured erythrocytes. The pathway is paly cytoplasmic and paly mitochondrial. Step 1: ALA synthesis - The synthesis stas with the condensation of succinyl CoA and glycine in the presence of pyridoxal phosphate to form delta amino levulinic acid (ALA). Hence, anemia may be manifested in pyridoxal deficiency. The enzyme ALA synthase is located in the mitochondria and is the rate-limiting enzyme of the pathway. REF: DM VASUDEVAN TEXTBOOK OF BIOCHEMISTRY, SIXTH EDITION,PG.NO.,325.