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Pathology General 1c0c0c03

Sickle cell trait patient do not have manifestations as that of Sickle cell disease, because-

A
50% HbS is required for occurrence of sickling
B
HbA prevents sickling
C
50% sickles
D
HbA prevents polymerization of Hbs
High-Yield Explanation
Sickle cell disease occurs in following forms Heterozygous state, i.e., sickle cell trait. Homozygous state, i.e., sickle cell anemia. The most important factor for sickling is the amount of HbS in the cell. In sickle cell trait (heterozygous state), only about 40% of the hemoglobin is HbS, this is insufficient to produce sickling manifestations. In homozygous state, almost all the hemoglobin in the red cell is HbS, therefore they undergo sickling.

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