A 32-year-old primigravida woman at 20 weeks with blood group O positive and her husband has blood group AB positive. Which of the following is the most appropriate response to this patient's query that she and her husband have different blood groups and have already a pregnancy to deal with ?
A
ABO antigens elicit only an IgM response which do not cross the placenta.
B
Antibodies to ABO antigens are not hemolytic
C
Newborns affected by ABO incompatibility will have only mild hemolytic disease
D
She is not at risk as the immune response is depressed during pregnancy