Radiology General 1b36be7e Eye of tiger sign on MRI is seen in A Hallervorden spatz syndrome B Progressive supra nuclear palsy C Early onset levodopa - responsive Parkinsonism D All of the above High-Yield Explanation The eye of tiger sign refers to abnormal low T2 signal on MRI in the globus pallidus with a logitudinal stripe of high signal (due to gliosis and spongiosis).