Hyperglycemia Associated with

The clinical manifestations resulting from the production of metabolic active substance by neoplastic tissue,have been labelled paraneoplastic syndrome.adolescent patients with osteosarcoma Demonstrate abnormal growth hormone ,insulin,growth hormone response to oral glucose loading in78% of the study population No statistical association exists between any of the two or three factors There fore no primary abnormality can be identified high somatomedin levels were noted 72%of group study accompanied by Simultaneous elevation of Growth hormone Study adrenal ,gonadal, gonadotropic hormone were essentially normal thrreby ruling these out as endocrine abnormalities Hyperglycemia is also aAssociated with condrosarcoma and fibrosarcoma