Hydrochlorothiazide works by inhibiting

Thiazide diuretics: Inhibits Na-Cl- sympoer in early DCT acts on distal tubule Includes- chlorothiazide, indapamide Decreases Na+, K+, Mg2+, H+ Increases glucose, uric acid, lipid Increase in calcium - used in osteoporosis Name Site of action Example Mechanism Loop diuretics Thick ascending limb of Loop of Henle Furosemide, Torsemide Na-K-2Cl sympoer inhibition Carbonic anhydrase inhibitors PCT Acetazolamide, Dorzolamide, Brinzolamide Carbonic anhydrase inhibition Thiazides DCT Hydrochlorothiazide, Chlohalidone Na-Cl sympoer inhibition Osmotic diuretics Non-specific Mannitol By osmotic effect Epithelial sodium channel blockers Collecting duct Amiloride, Triamterene eNa channel blockade Aldosterone antagonists Collecting duct Spironolactone, Eplerenone Antagonism of aldosterone receptors