Sweat chlorides are increased in:
High-Yield Explanation
The diagnosis of CF rests on the combination of clinical criteria and abnormal CFTR function as documented by sweat tests, nasal PD measurements, and CFTR mutation analysis. Elevated sweat Cl- values are nearly pathognomonic for CF. The sweat concentration values for Cl- (and Na+) vary with age, but, typically, a Cl- concentration of >70 meq/L in adults discriminates between CF and other lung diseases. Ref: Boucher R.C. (2012). Chapter 259. Cystic Fibrosis. In D.L. Longo, A.S. Fauci, D.L. Kasper, S.L. Hauser, J.L. Jameson, J. Loscalzo (Eds), Harrison's Principles of Internal Medicine, 18e.