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Pharmacology Sedative-Hypnotics and Parkinsonism 191b4287

A patient of DVT was stabilized on warfarin. This person was given phenobarbitone. Which of the following is the likely interaction between the two drugs?

A
Phenobarbitone increases the absorption of warfarin
B
Phenobarbitone increases the metabolism of warfarin
C
Phenobarbitone displaces warfarin from plasma protein binding sites
D
All of the above
High-Yield Explanation
-- Barbiturates like phenobarbitone are powerful enzyme inducers -- These increase the metabolism of warfarin and decrease its anticoagulant effect.
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