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Pathology General 186032e1

Necrotizing aerioritis with fibrionoid necrosis is ?

A
Immediate hypersensitivity
B
Cell mediated immunity
C
Antigen-antibody complex mediated
D
Cytotoxic cell mediated
High-Yield Explanation
Ans. is 'c' i.e., Antigen-antibody complex mediated The principal morphological manifestation of immune (antigen-antibody) complex injury is necrotizing vasculitis with necrosis of vessel wall and intense neutrophilic infiltration. The necrotic tissue and deposits of immune complexes, complement and plasma proteins produce a smudgy eosinophilic deposition that obscures the underlying cellular detail, an appearance termed fibrinoid necrosis.

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