Loss of heterozygosity associated with

Ref Robbins 9/e p292_293 familial case of retinoblastoma 1 defective and 1 normal gene at bih (heterozygous) second mutation causes both genes to be defective loss of heterozygosity Increased chances of cancer sporadic case of retinoblastoma both normal gene at bih _ homogeneous normal genes Both mutations occur somatic Ally within a single cell (homozygous abnormal genes ) increased chances of cancer