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Pharmacology Antimetabolites and Quinolones 1800615f

Mechanism of action of ciprofloxacin in gram negative bacteria:-

A
Inhibition of mycolic acid
B
Inhibition of topoisomerase IV
C
Inhibition of DNA gyrase
D
Inhibition of helicase
High-Yield Explanation
MECHANISM OF FLUOROQUINOLONES (FQ) In gram negative bacteria, FQ inhibit DNA gyrase by binding to its A subunit and interfere with cutting and resealing function. In gram positive bacteria, FQ inhibit similar enzyme DNA topoisomerase IV.

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