Full 2L QBank
Pharmacology Adverse Drug Effect 179884a7

Which antipsychotic has maximum hypotensive side effect?

A
Flufenazine
B
Trifluoperazine
C
Thioridazine
D
Haioperidol.
High-Yield Explanation
Ref: Goodman 3 Gill man. The pharmacological basis of therapeutics, 12'" edition, Pg No. 440 Basic and clinical Pharmacology by Betram Katzitng, 12th edition Pg No 508Explanation:Phenothiazines are classified into three groups: a. Aliphatic derivatives- Chlorpromazine h. Piperedine derivative- Thioradazine c. Piperazine derivative- Trifluoperazine, Perphenazine, fluphenazineAmong the above three, a & b are less potent and having more affinity for alpha 1 receptor and hence can cause more hypotensionPiperazine is pore potent typical and less affinity for alpha I receptor, hence less hypotensionButerophenones are the potent typical antipsychotic (haioperidol) having highest Extrapyramidal effects

Related Pharmacology MCQs

Practice 2,00,000+ NEET PG Questions Free

Timed mock tests, mistake queue analytics, audio lectures & zero attempt limits on i❤️Exams.

Start Free Mock Test Now