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Pathology General 1795194e

All are true about blood coagulation except?

A
Intrinsic pathway can be activated in vitro.
B
Extrinsic pathway is activated by contact of plasma with negatively charged surfaces.
C
Calcium is very important for coagulation.
D
Factor X is a part of both intrinsic and extrinsic pathway.
High-Yield Explanation
• Ataxia telangiectasiais an autosomal recessive condition. • Patients have increased sensitivity to x-ray-induced chromosome abnormalities. • Characterized by an ataxic-dyskinetic syndrome beginning in early childhood, caused by neuronal degeneration predominantly in the cerebellum, the subsequent development of telangiectasias in the conjunctiva and skin, and immunodeficiency. • The nuclei of cells in many organs (e.g., Schwann cells in dorsal root ganglia and peripheral nerves, endothelial cells as well as pituicytes) show a bizarre enlargement of the cell nucleus and are referred to as amphicytes. • The lymph nodes, thymus, and gonads are hypoplastic. • Clinical features include recurrent sinopulmonary infections and unsteadiness in walking. • Increased risk of development of lymphoid malignant disease (T-cell leukemia and lymphoma) All other options are autosomal dominant conditions.

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