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Pharmacology General 176cacf3

Anti-HIV drug combination that should not be used

A
Zidovudine + Stavudine
B
Atazanavir + Indinavir.
C
Didanosine/stavudine + Zalcitabine
D
All of the above.
High-Yield Explanation
Anti-HIV drug combinations that should NOT be used are: Zidovudine + Stavudine: Pharmacological antagonism (compete for intracellular phosphorylation) Atazanavir + Indinavir: Additive unconjugated hyperbilirubinemia. Didanosine/stavudine + Zalcitabine: Additive peripheral neuropathy. Lamivudine + Zalcitabine: In vitro antagonism.

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