Treatment of chronic phase of CML in pregnant women is -

Ans. is 'b' i.e., Leukapheresis Role of leukapheresis and spleenectomy in management of CML* Intensive leukapheresis may control the blood counts in chronic-phase CML; however, it is expensive and cumbersome.* It is useful in emergencies where leukostasis-related complications such as pulmonary failure or cerebrovascular accidents are likely.* It may also have a role in the treatment of pregnant women, in whom it is important to avoid potentially teratogenic drugs.* Splenectomy was used in CML in the past because of the suggestion that evolution to the acute phase might occur in the spleen.* However, this does not appear to be the case, and splenectomy is now reserved for symptomatic relief of painful splenomegaly unresponsive to imatinib or chemotherapy, or for significant anemia or thrombocytopenia associated with hypersplenism. Splenic radiation is used rarely to reduce the size of the spleen.