A 45 years old female patient presented painless supraclavicular lymphadenopathy. Biopsy revealed binucleated acidophilic owl eye appearance with floating lymphocytes in empty space, which was CD 15, CD 30 positive. What is the most probable diagnosis?

In a 45 years old female patient, who presented with painless supraclavicular lymph node enlargement. Biopsy revealed binucleated acidophilic owl eye appearance with floating lymphocytes in empty space, which was CD 15, CD 30 positive. The most probable diagnosis is Hodgkin's lymphoma. Nodular sclerosis, mixed cellularity and lymphocyte-depleted variants are positive for CD 15 and CD30. But Nodular sclerosis variant is most common type and more common in females. So, in the above-mentioned clinical situation, most probable diagnosis is nodular sclerosis variant of Hodgkin's lymphoma.Reed-Sternberg cells are large and are either multinucleated or have a bibbed nucleus (thus resembling an 'owl's eye' appearance) with prominent eosinophilic inclusion-like nucleoli. Reed-Sternberg cells are CD30 and CDI5 positive, usually negative for CD20 and CD45. The presence of these cells is necessary in the diagnosis of Hodgkin's lymphoma - the absence of Reed-Sternberg cells has very high negative predictive value.Nodular sclerosis:Nodular sclerosis is MC type all over the worldQNodular sclerosis is MC in femalesIt has propensity to involve the cervical, supraclavicular and mediastinal lymph nodes of adults and adolescentsLacunar cells of Reed Sternberg cells variant is seen