Fatty liver with Hepatomegaly is seen in:-

Metabolic syndrome: Central obesity Insulin resistance Hyperglycemia Risk of dyslipidemia Diabetes On HPE examination of fatty liver, macro vesicular steatosis is seen. Lipid accumulates inside hepatocytes forming vacoules which gives clear appearance on staining. Wilson's disease: ATP 7B gene defect Body retains excess copper Kayser Fleischer ring ( Brown ring on the edge of cornea) Thesunflowercataract inWilson's disease is pathognomonic sign . Predominant presentation includestremor, dysphasia, ,dysahria , neuropsychiatric manifestations , gait and limb ataxia Nutmeg liver: Associated with chronic venous congestion of liver Dark spots represent dilated and congested hepatic venules and small hepatic veins Marasmus: Due to deficiency of proteins and calories Lean appearance Oedema is absent No fatty liver