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Pathology General 168c379a

Pathognomic finding of rabies is: March 2012

A
Obliterative endaeritis
B
Microglial nodules
C
Neuronophagia
D
Negri bodies
High-Yield Explanation
Ans: D i.e. Negri bodiesPathologic changes and associated conditionsIn tuberculosis, aeries running through the subarachnoid space may show obliterative endaeritis with inflammatory infiltrates in their walls and marked intimal thickeningHIV encephalitis is best characterized microscopically as a chronic inflammatory reaction with widely distributed infiltrates of microglial nodules, sometimes with associated foci of tissue necrosis and reactive gliosisAcute cases of poliomyelitis show mononuclear cell perivascular cuffs and neuronophagia of the anterior horn motor neurons of the spinal cordNegri bodies, the pathognomic microscopic finding of rabies, are cytoplasmic, round to oval, eosinophilic inclusions that can be found in pyramidal neurons of the hippocampus and Purkinje cells of the cerebellum, sites usually devoid of inflammation.

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