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Surgery General 161e630d

Orphan Annie nuclei" is seen in?

A
Papillary carcinoma of thyroid
B
Medullary carcinoma of thyroid
C
Anaplastic carcinoma of thyroid
D
Follicular carcinoma of thyroid
High-Yield Explanation
Papillary carcinoma of thyroid REF: Schwaz's Principles of Surgery 9' edition chapter 38 Histologically, papillary carcinomas may exhibit papillary projections, a mixed pattern of papillary and follicular structures, or a pure follicular pattern (follicular variant). The diagnosis is established by characteristic nuclear cellular features. Cells are cuboidal with pale, abundant cytoplasm, crowded nuclei that may demonstrate "grooving," and intranuclear cytoplasmic inclusions leading to the designation of Orphan Annie nuclei, which allow diagnosis by FNAB.

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