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Pharmacology General 157b56fc

Which of the following inhibits transcription ?

A
Cyclosporine
B
Rapamycin
C
5-Flurouracil
D
Cyclophosphamide
High-Yield Explanation
Ans. is 'a' i.e., Cyclosporine Cyclosporine inhibits transcription by binding to a protein called cyclophilin. This complex then inactivates calcineurin. (Calcineurin is a protein which is responsible for the transcription of cytokine gene)

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