Gamma Glutamyl Transferase is increased in

(A) Alcoholic hepatitis # Function of GGT:> It is involved in the transfer of amino acids across the cellular membrane and in glutathione metabolism.> Location> GGT is found in high concentrations in the liver, bile ducts and kidney.> Enzyme is also present in other tissues, such as the epididymis.> Clinical significance Congestive heart failure Cholestasis (congestion of the bile ducts) Cirrhosis of the liver Restricted blood flow to the liver Restricted venous outflow from liver like Budd-Chiari syndrome Necrosis of the liver Liver tumors Hepatitis Hepatotoxic drugs> Its levels are increased in chronic and acute alcohol abuse.