Which of the following hematological condition is depicted below?
High-Yield Explanation
Ref. Robbins Pathology. 9th edition. Page. 620
The picture shows many atpical plasma cells – Diagnostic of Myeloma
Malignant proliferation of plasma cells characterised by monoclonal gammaglobulinaemia (paraproteinaemia)
Cell of origin – Post germinal centre B cells
Stages
MGUS
Smoldering myeloma
Myeloma
MGUS – most common plasma cell dyscrasia
Myeloma – CRAB Features
Hypercalcemia
Renal Insufficiency
Anemia
Bone lytic lesions