Acute Gouty ahritis is seen early in treatment following

Allopurinol REF: Goodman Gillman manual of pharmacology and therapeutics 2008 edition page 458 "The incidence of acute attacks of gouty ahritis mayincrease duringthe early months of allopurinol therapy as a consequence of mobilization of tissue stores of uric acid. Co-administration of colchicine helps suppress such acute attacks. After reduction of excess tissue stores of uric acid, the incidence of acute attacks decreases and colchicine can be discontinued"