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Pathology Haematology 14319bea

CD 19 positive, CD22 positive, CD103 positive monoclonal B-cells with bright kappa positivity were found to comprise 60% of the peripheral blood lymphoid cells on flow cytometric analysis in a 55 year old man with massive splenomegaly and a total leucocyte count 3.3 x 109/L. Which one of the following is the most likely diagnosis -

A
Splenic lymphoma with villous lymphocytes
B
Mantle cell lymphoma
C
B-cell prolymphocytic leukemia
D
Hairy cell leukemia
High-Yield Explanation
Hairy cell leukaemia: Constitutes about 2% of all leukaemia. Male:female: :5:1,middle aged white males predominant , median age :55; Immunophenotype: typically express pan-Bcell markers CD19&CD20, surface Ig(usually IgG) & ceain relatively distinctive markers , such as CD11c,CD25 ,CD103 and annexin A1. Ref:Robbins pathologic basis of disease ,pg:603,604

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