Genetic risk factor for COPD is

Severe a1 Antitrypsin deficiency is a proven genetic risk factor for COPDAlthough only approximately 1% of COPD patients are found to have severe a1AT deficiency as a contributing cause of COPD, these patients demonstrate that genetic factors can have a profound influence on the susceptibility for developing COPDSpecific treatment in the form of a1AT augmentation therapy is available for severe a1AT deficiency as a weekly IV infusion Patients with cystic fibrosis develop bronchiectasisRef: Harrison 19e pg: 1704