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Pediatrics Childhood Tumors 140e10e5

Retinoblastoma gene is located on:

A
Chromosome 5
B
Chromosome 8
C
Chromosome 13
D
Chromosome 16
High-Yield Explanation
c. Chromosome 13(Ref: Nelson's 20/e p 2476-2478, Ghai 8/e 614-615)Retinoblastoma (RB) geneIt is located on chr 13q14; its mutation or deletion is responsible for hereditary form of RetinoblastomaIt encodes the retinoblastoma protein, a tumor suppressor protein that controls cell-cycle phase transition and has roles in apoptosis and cell differentiation

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