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Pathology General 13bfc48f

All of the following are true about multiple myeloma except-

A
Osteolytic bone disease
B
t (18-14) translocation
C
Light chain proliferation
D
Bence-Jones proteins in urine
High-Yield Explanation
Ans. is 'b' i.e., t (8-14) translocationGenetics of multiple myeloma,o A variety of chormosomal abnormalities occur with multiple myeloma.o Most common chromosomal translocation seen with multiple myeloma is t (11 : 14) (q13 : q32) Other chromosomal abnormalities are 13814 deletions, 17813 deletions, Overexpression of ras or myc gene.

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