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Pharmacology Parasympathetic System & Glaucoma 1369d5b9

Which of the following provides the best explanation for neostigmine being preferred over physostigmine for treating myasthenia gravis?

A
It is better absorbed orally
B
It has longer duration of action
C
It has additional direct agonistic action on nicotinic receptors at the muscle end plate
D
It penetrates blood brain barrier
High-Yield Explanation
Neostigmine is a quaternary ammonium derivative and is water soluble. Its absorption from GIT and penetration in the brain and cornea is much less than physostigmine. It produces additional action on NM receptors.
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