Hepatosplenomegaly is not seen in: March 2010

Ans. C: Sickle cell disease Some of the common medical causes of hepatosplenomegaly include: Leukemia Lymphoma Bilia atresia Bile duct carcinom Budd Chiari syndrome Spherocytosis Cirrhosis Hepatitis Malaria Thrombocytosis Patient with sickle cell disease often suffer from autosplenectomy as a result of splenic destruction by the numerous infarcts associated with the sickle cell crisis during childhood. Indeed presence of a palpable spleen in a patient with sickle cell disease after age 5 suggests a coexisting hemoglobinopathv