All of the following are recommendations for screening of lynch syndrome in women with endometrial cancer except
High-Yield Explanation
Lynch syndrome Genetic Screening Recommendations
Patients with endometrial or colorectal cancer and tumor evidence of:
Microsatellite instability or
DNA mismatch repair protein loss
Fisrt-degree relative with endometrial or colorectal cancer who was diagnosed:
Before age 60 years or
Is at risk for Lynch syndrome based on personal and medical history.
First- or second-degree relative with a known DNA mismatch repair gene mutation.