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Gynaecology & Obstetrics General 13273cec

All of the following are recommendations for screening of lynch syndrome in women with endometrial cancer except

A
Evidence of microsatellety instability
B
DNA mismatch repair protein loss
C
Endometrial cancer before 60 years of age
D
1st or 2nd degree relative with known DNA mismatch repair gene mutation
High-Yield Explanation
Lynch syndrome Genetic Screening Recommendations Patients with endometrial or colorectal cancer and tumor evidence of: Microsatellite instability or  DNA mismatch repair protein loss Fisrt-degree relative with endometrial or colorectal cancer who was diagnosed: Before age 60 years or  Is at risk for Lynch syndrome based on personal and medical history. First- or second-degree relative with a known DNA mismatch repair gene mutation.

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