Medicine General 123549dc Mechanism of action of Orlistat used to treat obesity is which of the following? A Central reuptake inhibitor of both norepinephrine and serotonin B Intestinal lipase inhibitor C Central reuptake facilitator of serotonin D Intestinal amylase inhibitor High-Yield Explanation Sibutramine is central reuptake inhibitor of Noradrenaline and serotonin. Orlistat is a intestinal lipase inhibitor.