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Microbiology All India exam 11fe5689

Which of the following enzyme is involved in process of both cholesterol and ketone bodies synthesis?

A
HMG CoA reductase
B
HMG CoA synthase
C
HMG CoA lyase
D
Thiolase
High-Yield Explanation
This enzyme is involved in both cholesterol synthesis as well as in ketone body synthesis.HMG CoA reductase is the rate-limiting enzyme of the cholesterol synthesis.HMG CoA lyase is the enzyme involved in ketone body synthesis.Thiolases are also known as acetyl-Coenzyme A acetyltransferases (ACAT), which are enzymes which conve two units of acetyl-CoA to acetoacetyl CoA in the mevalonate pathway. Thiolases are ubiquitous enzymes that have key roles in many vital biochemical pathways, including the beta-oxidation pathway of fatty acid degradation and various biosynthetic pathways.

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